CITI Training Practice Exam

Which phase typically involves larger, placebo-controlled, and double-blinded studies?

1. Phase I

2. Phase II

3. Phase III

4. Phase IV

The correct answer is: Phase III

Phase III is typically the last phase of clinical trials before a drug or treatment is approved for use by the general public. This phase typically involves larger studies, including thousands of participants, to further evaluate the safety and effectiveness of the treatment. Additionally, these studies are often placebo-controlled, meaning some participants receive a placebo or inactive substance instead of the treatment, and double-blinded, meaning neither the researchers nor the participants know who is receiving the treatment and who is receiving the placebo. This helps to eliminate bias and accurately assess the results of the treatment. Options A, B, and D are incorrect because they are either earlier phases of clinical trials or not directly involved in the approval process.